Preparation and evaluation of solid dispersions of cefpodoxime proxetil

Solid dispersions (SDs) are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. This technology is mainly applied to improve the solubility of Class II and Class IV drugs. Cefpodoxime proxetil (CP) is chosen as drug as it belongs to Class IV i. e. having low solubility and low permeability (Solubility: 400 μg/ml). SDs were prepared by using PVPK 30 as carrier/ polymer by varying Drug: Polymer ratio (D: P). Two techniques were used for preparing SDs viz Kneading and Spray drying. Prepared SDs were evaluated for drug content, Saturation solubility, pH dependent solubility, D0 value, and dissolution studies. From results of above studies, optimized SDs were decided which were further characterized for SEM, XRD, DSC and finally antimicrobial activity Studies. From the results obtained from above studies, it can be concluded that, solubility and dissolution of CP was improved as compared to pure drug and physical mixtures. Hence, Solid dispersion technology can be used to improve the solubility of CP.